
I've been using TweetDeck now for several months. Except for its propensity to swallow memory, I think it's probably one of the best Twitter interfaces out there.
If you don't already use it, I'd highly recommend you
give TweetDeck a go.
Recent updates have extended the service further to offer Facebook integration and other nice features like TwitPic previews.
One of the useful features I use on Tweetdeck daily is the facility to set up groups.
Groups allow me to follow defined collectives of Twitter users for specific reasons.
Amongst my groups I have "work colleagues", "web PM's" and "SEO" to name a few.
Whenever a member of a group posts a tweet it alerts you via the usual pop-up message, but defining which group has posted.
If you've got some work relating to a specific sector or project area its very hand for staying in touch with a subject as it develops.

To create a group use the icon on the top TweetDeck toolbar, upon click this will create a new coloumn within the TweetDeck window. From here you simply name your group, then click the check boxes next to the users you want to be part of that group, finally save the group.
TweetDeck will create a new column in the application windo
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